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As an upstream event of ferroptosis, autophagy activation can induce ferroptosis through different mechanisms, including NCOA4-mediated ferritin autophagy [95], RAB7A-mediated lipid autophagy [96], ARNTL-mediated biological clock protein autophagy [97], and BECN1-mediated System X c inhibition [64]

Candidates should have realistic expectations, commitment to lifestyle modification, and absence of contraindications such as severe liver disease, choline sensitivity, or uncontrolled comorbidities